Literat, A., Su, F., Norwicki, M., Durand, M., Ramanathan, R., Jones, C. A., Minoo, P., and Kwong, K. Y. Regulation of pro-inflammatory cytokine expression by curcumin in hyaline membrane disease (HMD). Zhang, W., Liu, D., Wo, X., Zhang, Y., Jin, M., and Ding, Z. Effects of Curcuma Longa on proliferation of cultured bovine smooth muscle cells and on expression of low density lipoprotein receptor in cells. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Dorai, T., Cao, Y. C., Dorai, B., Buttyan, R., and Katz, A. E. Therapeutic potential of curcumin in human prostate cancer. Li, W. Q., Dehnade, F., and Zafarullah, M. Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway. Thresiamma, K. C., George, J., and Kuttan, R. Protective effect of curcumin, ellagic acid and bixin on radiation induced genotoxicity.
A systematic review and meta-analysis of randomized controlled trials. Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome - a double blind randomized controlled trial - TAK-MetS trial. A placebo-controlled double-blind study demonstrates the clinical efficacy of a novel herbal formulation for relieving joint discomfort in human subjects with osteoarthritis of knee. Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial.
Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., and Srinivas, P. S. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Ranjan, D., Siquijor, A., Johnston, T. D., Wu, G., and Nagabhuskahn, M. The effect of curcumin on human B-cell immortalization by Epstein-Barr virus. Mehta, K., Pantazis, P., McQueen, T., and Aggarwal, B. B. Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. Kuo, M. L., Huang, T. S., and Lin, J. K. Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells. Oetari, S., Sudibyo, M., Commandeur, J. N., Samhoedi, R., and Vermeulen, N. P. Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver. Srivastava, K. C., Bordia, A., and Verma, S. K. Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets. Srinivasan, M. Effect of curcumin on blood sugar as seen in a diabetic subject.
The testosterone and DHT levels were increased from 0.51 to 1.09 pg per assay and 0.95 to 1.17 pg per assay, respectively (data not shown). We also examined the testosterone and DHT levels in LNCaP cells treated with siRNA of AKR1C2. In LNCaP, cDNA microarray analysis identified AKR1C2 as a factor in androgen metabolism and verified that curcumin increases its expression. Signal transduction aiding androgen and androgen receptors plays an important role, by governing propagation and differentiation of prostate cancer cells. Many prostate cancer cells undergo androgen‐dependent proliferation. In our study, we estimated that approximately 10 times the circulating concentration of curcumin was used in in vitro (50 μmol/L) and in vivo (200 mg/kg/d) experiments compared with this clinical trial.
The main findings of this review indicate that some herbs, particularly fenugreek seed extracts and ashwagandha extracts, have positive effects on testosterone concentrations in men. Eight weeks of daily supplementation with 2.4 g of a cordyceps extract in 16 healthy men aged between 19 and 25 y did not significantly increase testosterone concentrations compared with the placebo group. Twelve weeks of daily supplementation with 1.0 g of a musali extract in 40 healthy men, aged between 20 and 40 y, did not significantly increase testosterone concentrations compared with the placebo group.
Size and thickness of epithelial cell in ventral lobe of prostate tissue was assessed in order to identify effect of curcumin on BPH. The rest of the prostate were stored at −70 °C for the later analysis. After animals were sacrificed, fresh prostate was stored in formaldehyde solution for light microscopic observation.

Gender: Female

Social links